| 2010 Season |
| Date | Opponent | Location | Time | Network |
| Sep 04, 2010 | Marshall | Columbus, Ohio | | |
| Sep 11, 2010 | Miami (FL) | Columbus, Ohio | | |
| Sep 18, 2010 | Ohio | TBD | | |
| Sep 25, 2010 | Eastern Michigan | Columbus, Ohio | | |
| Oct 02, 2010 | Illinois | Champaign, Ill. | | |
| Oct 09, 2010 | Indiana | Columbus, Ohio | | |
| Oct 16, 2010 | Wisconsin | Madison, Wisc. | | |
| Oct 23, 2010 | Purdue | Columbus, Ohio | | |
| Oct 30, 2010 | Minnesota | Minneapolis, Minn. | | |
| Nov 13, 2010 | Penn State | Columbus, Ohio | | |
| Nov 20, 2010 | Iowa | Iowa City, Iowa | | |
| Nov 27, 2010 | Michigan | Columbus, Ohio | | |
| 2011 Season |
| Date | Opponent | Location | Time | Network |
| Sep 03, 2011 | Akron | Columbus, Ohio | | |
| Sep 10, 2011 | Toledo | Columbus, Ohio | | |
| Sep 17, 2011 | Miami (FL) | Miami, Fla. | | |
| Oct 01, 2011 | Michigan State | Columbus, Ohio | | |
| Oct 08, 2011 | Penn State | University Park, Penn. | | |
| Oct 15, 2011 | Open | Columbus, Ohio | | |
| Oct 22, 2011 | Minnesota | Columbus, Ohio | | |
| Oct 29, 2011 | Indiana | Bloomington, Ind. | | |
| Nov 05, 2011 | Northwestern | Columbus, Ohio | | |
| Nov 12, 2011 | Purdue | West Lafayette, Ind. | | |
| Nov 19, 2011 | Iowa | Columbus, Ohio | | |
| Nov 26, 2011 | Michigan | Ann Arbor, Mich. | | |
| Future Major OOC Opponents |
| Date | Opponent | Location | Time | Network |
| 2012 | California | | | |
| 2013 | California | | | |
| Aug 30, 2014 | Navy | | | |
| 2014 | Virginia Tech | | | |
| 2015 | Virginia Tech | | | |
| Sep 17, 2016 | Oklahoma | Norman, Okla. | | |
| Sep 16, 2017 | Oklahoma | Columbus, Ohio | | |
| Sep 01, 2018 | Tennessee | Knoxville, Tenn. | | |
| Sep 07, 2019 | Tennessee | Columbus, Ohio | | |